Featured Review: Antifibrinolytics for heavy menstrual bleeding

Heavy menstrual bleeding? Updated Cochrane evidence from the Cochrane Gynaecology and Fertility Group shows Antifibrinolytic medication may help.

"Antifibrinolytic medication may improve Heavy Menstrual bleeding (HMB) in women aged 15 to 50 years old, without substantially increasing the rate of adverse events. Evidence suggests there is a 40% to 50% reduction in the amount of menstrual blood lost per menstrual cycle for participants taking tranexamic acid (TXA). Antifibrinolytic treatment was better at improving HMB loss than other medical treatments, except for the levonorgestrel intrauterine system (LIUS), a plastic device placed in the uterus which releases hormone to prevent conception.

The evidence suggests that if 10.9% of women taking placebo report an improvement in HMB, 36.3% of women taking TXA will do so.

TXA probably improves quality of life for women with HMB."